| abstract |
The present invention relates to oligonucleotide-coded libraries and methods for tagging the libraries. In particular, the present methods and oligonucleotides can be used in combination with one or more 2'-substituted nucleotides such as 2'-O-methyl or 2'-fluoronucleotides, and other conditions or reagents to enhance enzymatic ligation, May include one or more chemical functionalities that support it. |