| abstract |
The main object of the present invention is to provide a novel heterocyclic derivative or a pharmaceutically acceptable salt thereof. As the present invention, there can be mentioned, for example, a heterocyclic derivative represented by the following chemical formula [1] or a tautomer thereof or a pharmaceutically acceptable salt thereof. (Wherein R 1 and R 2 are the same or different and represent an aromatic ring and the ring A represents a heterocycle). The compound of the present invention or a pharmaceutically acceptable salt thereof has a high mPGES-1 inhibitory activity and is useful as a medicament for treating mPGES-1-related diseases such as arthritic rheumatism, deformed arthropathy, jaw arthropathy, back pain, endometriosis, Active bladder, malignant tumor or neurodegenerative disease. |