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publicationDate 2014-05-08-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber KR-20140054127-A
titleOfInvention Polymer nanoparticles for photosensitizers
abstract Biodegradable polymeric nanoparticles comprising an inner core formed of a photodynamic component that can be activated to generate cytotoxic singlet oxygen are prepared. These nanoparticles have anti-cell proliferative activity and are useful in the treatment of both non-cancerous conditions including cancer and actinic keratosis, psoriasis and acne vulgaris. Preferably, the photodynamic component is a hypocrelin B derivative while the polymer nanoparticle comprises polyglycolic acid, polylactic acid or poly (lactide-co-glycolide). Hypocrelin-containing nanoparticles are described as being capable of being activated by light or hydrogen peroxide.
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