abstract |
The present invention relates to a practically pure metabolite of trans-clomiphene and a pharmaceutically acceptable salt thereof, preferably a citric acid salt. Pharmaceutical compositions containing substantially pure metabolites of trans-clomiphene or salts thereof are also provided. The present invention also relates to a pharmaceutical composition comprising such metabolites and to a pharmaceutical composition comprising such metabolites and to a method for the treatment and prophylaxis of a condition selected from the group consisting of secondary gonadal hypoglycemia, Type 2 diabetes, increased cholesterol, increased triglycerides, fatigue, lipodystrophy, Prostate cancer, breast cancer, ovarian cancer, and endometrial cancer. |