| abstract |
The present application relates to taste-masked multi-layered particles comprising a pharmaceutically active ingredient, wherein the particles comprise (a) an inert core, (b) at least one coating layer comprising the pharmaceutical active ingredient and a binder ), (c) an intermediate coating layer (seal coating) that does not have a low molecular weight water soluble ionic compound, including water-soluble pharmaceutical film-forming compounds selected from (i) HPMC and PEG or (ii) d) a low molecular weight water soluble ionic polymeric material comprising a mixture comprising (i) poly (meth) acrylate or (ii) 60 to 90% (w / w) EC and 10 to 40% (w / (Final or taste-masking coating) having no compound, wherein the pharmaceutically active ingredient is water-soluble and comprises at least one of a basic group and / or a bitter taste. Methods of making such particles and pharmaceutical compositions containing them are further described. |