| abstract |
The present invention relates to methyl sulfonamides and N-formamide derivatives of the general formula (1) below, and methods for their synthesis. The invention also provides pharmacological compositions using these derivatives, and asthma, rheumatoid arthritis, COPD, rhinitis, degenerative arthritis, psoriatic arthritis, psoriasis, characterized by overexpression and overactivation of matrix metalloproteinases using the compounds. Pulmonary fibrosis, pneumonia, acute respiratory distress syndrome, periodontitis, multiple sclerosis, gingivitis, atherosclerosis, dry eye, restenosis and ischemic heart failure, causing endovascular hyperplasia, stroke, kidney disease or tumor metastasis and other inflammatory diseases Provides a way to treat it. [Chemical Formula 1] |