abstract |
The present invention relates to improved immunogenic compositions and vaccines, methods of making them and their use in medicine. In particular, the present invention includes member (s) (eg, PhtD) of the pneumolysin and polyhistidine triad family, which comprise an adjuvant comprising QS21 and monophosphoryl lipid A (MPL) and are provided in the form of liposomes. And an immunogenic composition of unconjugated Streptococcus pneumoniae protein selected from |