| abstract |
The present invention provides a pharmaceutical composition for the prevention or treatment of inflammation or skin aging comprising small peptide fragments (small peptide fragments) derived from the p65 subunit of NF-κB as an active ingredient. In addition, the present invention provides a cosmetic composition for improving inflammation or skin aging comprising the peptide fragment. The peptide has anti-inflammatory activity by inhibiting the expression of various inflammatory mediators whose expression is induced by NF-κB activity and inhibiting extravasation of leukocytes. Further, the PGE 2 as an inflammatory mediator factor is increased by UV light stimulation, suppress transcription that inflammatory mediators of MMP-1, the expression of TNF-α, and IL-1α by NF-κB and inflammatory mediator molecule And suppresses the expression of COX-2, an enzyme that mediates the production and the mediating action, thereby having skin photoaging inhibition activity. |