http://rdf.ncbi.nlm.nih.gov/pubchem/patent/KR-20140021467-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_adff709a8d25eaa0d3871ff46ff250eb |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-24 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-34 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-107 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-127 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-0019 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-122 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K9-107 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K9-127 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-30 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-122 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 |
| filingDate | 2011-03-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_368f64f46eb505f828fe8e9e53252d94 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_9ecf5874b7b757deef6ee5b1e36af957 |
| publicationDate | 2014-02-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | KR-20140021467-A |
| titleOfInvention | Intravenous formulation of coenzyme # 10 (CｏＱ10) and methods of use thereof |
| abstract | Described herein are formulations suitable for parenteral administration of certain hydrophobic active agents, such as coenzyme Q10. Also provided herein are methods of making the same and methods of treating oncological disorders using the same. The formulation is an aqueous solution; Hydrophobic actives that are dispersed to form colloidal nano-dispersions of the particles; And a dispersion stabilizer and an opsonization reducer, wherein the colloidal nano-dispersion of the active agent is dispersed into nano-dispersion particles having an average size of less than 200-nm. Methods for preparing parenteral formulations include (1) forming a hydrophobic active agent / water mixture by adding hydrophobic active agent to a water bath at 65 ° C. and mixing; (2) adding a dispersion stabilizer to the hydrophobic active agent / water mixture and mixing at 65 ° C. to form a hydrophobic active agent / water / stabilizer mixture; (3) adding an opsonization reducer to form a hydrophobic active agent / water / stabilizer / opsonization reducer mixture; (4) pre-heating the microfluidizer to 65 ° C; And (5) processing the hydrophobic active agent / water / stabilizer / opsonization reducer mixture in a microfluidizer at 65 ° C. to form a hydrophobic active agent colloidal nano-dispersion having an average particle size of less than 200-nm. Dispersing the hydrophobic active agent by high pressure homogenization with. Also provided herein is a method of treating an oncological disorder by causing the treatment or prevention of an oncological disorder by administering a formulation described herein to a subject. |
| priorityDate | 2010-03-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
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