| abstract |
Compounds that act as selective antagonists of the transient receptor translocation cation pathway subfamily M member 8 (hereinafter referred to as TRPM8) bearing the following compounds: From here R is selected from: H, Br, CN, NO 2 , SO 2 NH 2 , SO 2 NHR ′ and SO 2 N (R ′) 2 , wherein R ′ is from linear or branched C 1 -C 4 alkyl Is selected; X is selected from: F, Cl, C 1 -C 3 alkyl, NH 2 and OH Y is selected from: O, CH 2 , NH and SO 2 R 1 and R 2 are independently of one another selected from: H, F and linear or branched C 1 -C 4 alkyl; R 3 and R 4 are independently of each other selected from: H and linear or branched C 1 -C 4 alkyl; Z is selected from: NR 6 and R 6 R 7 N + , wherein R 6 and R 7 are independently of each other selected from: H and linear or branched C 1 -C 4 alkyl R 5 is a residue selected from: H and linear or branched C 1 -C 4 alkyl Het is derived from substituted or unsubstituted pyrroyl, substituted or unsubstituted N-methylpyrroyl, substituted or unsubstituted thiophenyl, substituted or unsubstituted furyl and substituted or unsubstituted pyridinyl Selected heteroaryl group. The compounds are useful for the prevention and treatment of pathologies dependent on TRPM8 activity, such as pain, inflammation, ischemia, neurodegeneration, seizures, psychotic disorders, inflammatory conditions and urinary disorders. |