| abstract |
The present invention provides novel 3,4-dihydro-pyrrolo [1,2-a] pyrazine as an inhibitor of beta-secretase, also known as beta-site amyloid cleavage enzyme, BACE, BACE1, Asp2 or memapsin2. It relates to a 1-ylamine derivative. The present invention also provides pharmaceutical compositions comprising such compounds, methods of making such compounds and compositions, and disorders involving beta-secretase, such as Alzheimer's disease (AD), mild cognitive impairment, senility ), Dementia, Lewy body dementia, Down syndrome, stroke related dementia, Parkinson's disease related dementia or beta-amyloid related dementia. (I) |