| abstract |
The present invention relates to a composition for preventing or treating hyperlipidemia, fatty liver disease or arteriosclerosis, which comprises oxytomodulin derivative as an active ingredient. The oxytomodulin derivatives of the present invention have high activity against the GLP-1 receptor and glucagon receptor as compared to the native oxytomodulin, as well as increased serum total cholesterol, low density cholesterol and triglyceride And has the effect of increasing the ratio of high density cholesterol and high density cholesterol / low density cholesterol. Therefore, it can be usefully used in the treatment of hyperlipemia and related diseases. |