| abstract |
The present invention relates to a substrate covalently bound to an antimicrobial polymer, and functions as a synthetic mimics of antimicrobial peptides (SMAMPs), preferably ring opening metathesis polymerization (ROMP). For the substrate obtained by The advanced antimicrobial polymer has a molecular weight of at least 100,000 g mol −1 and is preferably covalently bound to the surface of the substrate, for example an implant, medical device, medical device or (tissue-supported) biomaterial or the like. . Covalent bonding can be performed using photoreactive crosslinkers by "grafting onto" or "grafting from". The present invention also relates to the use of the advanced antimicrobial polymers defined herein, for example the use of an antimicrobial coating of said advanced antimicrobial polymer on the surface of such substrate. |