| abstract |
The present invention provides novel formulations with, in particular, polysaccharide-protein conjugates that mitigate shaking-induced aggregation of immunogenic compositions. In particular, the novel formulations comprise poloxamers in the molecular weight range of 1100 to 17,400 which provide significant advantages over previously used surfactants including polysorbate 80. In one embodiment, the present invention provides multivalent immunogenic compositions having 15 distinct polysaccharide-protein conjugates and poloxamers. Each conjugate is composed of several serotypes of Streptococcus pneumoniae (1, 3, 4, 5, 6A, 6B, 7F, 9V, 14, 18C, 19A, conjugated to a carrier protein, preferably CRM 197 ). Coated polysaccharides prepared from 19F, 22F, 23F or 33F). <Representative figure> 1b |