| abstract |
Localizing the therapeutic agent to the coagulation site (eg, by targeting to platelets or activating at the coagulation site) and having reduced clearance, improved manufacturability, reduced thrombusogenesis, or enhanced activity Chimeric coagulation factors having, or having one or more of these features are described, and also methods for making chimeric coagulation factors and methods for improving hemostasis using these coagulation factors are described. |