http://rdf.ncbi.nlm.nih.gov/pubchem/patent/KR-20140000275-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_68c213ba9952360f439567152e047b18 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K45-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-496 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-0014 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D405-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P31-18 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-496 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P31-18 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D405-14 |
| filingDate | 2011-11-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_9b99100c6088e510f07b823079881bb9 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_2636f162fbd5ac2b0d619d4c613b4c15 |
| publicationDate | 2014-01-02-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | KR-20140000275-A |
| titleOfInvention | Bifunctional molecule with antibody recruitment and entry inhibitory activity against human immunodeficiency virus |
| abstract | The present invention relates to novel bifunctional compounds and methods of treating HIV infection. It provides a bifunctional small molecule, commonly called ARM-HI, to meet the need for new therapeutic strategies for HIV infection. The ARM-HI prevents cellular infection and the spread of HIV through the orthogonal pathway-inhibition of the interaction of gp120-CD4, and recruitment of anti-DNP antibodies to gp120 expressing cells. ARM-HI competitively binds CD4 to gp120 and gp-120 expressing cells, inhibits viral infection as shown in MT-2 cell analysis, recruits anti-DNP antibodies that bind to it to form a ternary complex, Antibodies present in this ternary complex promote complement-dependent destruction of gp120 expressing cells. Compounds and methods are described herein |
| priorityDate | 2010-11-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 567.