abstract |
Therapeutic compositions and / or formulations comprising one or more crosslinked protein matrices comprising one or more protein residues and one or more saccharide-containing residues are provided, and methods of making the same. Crosslinking protein matrices may comprise full-length or substantially full-length proteins such as tropoelastin, elastin, albumin, collagen, collagen monomers, immunoglobulins, insulin and / or derivatives or combinations thereof, including saccharide-containing crosslinkers, for example And crosslinking with a polysaccharide crosslinker derived from hyaluronic acid or a cellulose derivative. The therapeutic composition may be administered topically or by injection. The present disclosure also provides methods, systems and / or kits for the preparation and / or formulation of the compositions disclosed herein. |