| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_fbcd29a78d25494a4ec34568bfc817ff |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07B2200-07 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-4545
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D401-12
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07B53-00 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D401-12
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P37-08
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-4545 |
| filingDate |
2012-06-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6c2e7cb041b1fa467e0fd885f1f60660
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_2b7fa189755a4702e2495fefd9291300 |
| publicationDate |
2013-12-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
KR-20130136346-A |
| titleOfInvention |
Process for preparing bepotastine and novel intermediates used in the preparation thereof |
| abstract |
The present invention a) (RS) -4-[(4-chlorophenyl) (2-pyridyl) methoxy] piperidine racemate of formula (2) in the presence of a base in an organic solvent Reacting with a) -bornyl ester compound to obtain a (S) -bepotastine (-)-bornyl ester of the formula (4); b) reacting the compound of Formula 4 with an organic acid in an organic solvent to obtain an organic acid salt of Formula 5; c) reacting the obtained organic acid salt in the presence of a base to liberate the compound of Formula 4; And d) hydrolyzing the liberated compound of Formula 4 in the presence of a base, thereby providing a method of preparing (S) -bepotastine. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/KR-20160132536-A |
| priorityDate |
2012-06-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |