| abstract |
The present invention provides novel compounds (I) having antiviral activity, in particular HIV enzymatic inhibitory activity and drugs comprising the same, in particular anti-HIV drugs, as well as processes and intermediates thereof. Compound (I) Wherein Z 1 is NR 4 ; R 4 is hydrogen or lower alkyl; X is a heteroatom group selected from a single bond, O, S, SO, SO 2 and NH (each of lower alkylene or lower alkenylene may be interrupted by such heteroatoms); R 2 is substituted or unsubstituted aryl; R 3 is hydrogen, halogen, hydroxy, substituted or unsubstituted lower alkyl, or the like; And R 4 and Z 2 together form a ring to form a polycyclic compound such as a tricyclic or tetracyclic compound. |