| abstract |
The present invention relates to a modified tamabidin 2, comprising an amino acid sequence as set forth in SEQ ID NO: 2, or an amino acid sequence having a plurality of amino acid mutations in the sequence 1 or an amino acid sequence having at least 80% identity with the sequence. In the protein showing biotin binding activity, a modified biotin binding protein is provided, wherein the 115th asparagine residue of SEQ ID NO: 2 is substituted with cysteine. The modified biotin binding protein of the present invention exhibits remarkable heat resistance. |