| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_e449b0ad7e617a470f1354343201c7b1 |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y02P20-55 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K17-08
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K1-068
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-16
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K1-062
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K1-04
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C08F112-08
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K5-06086
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K5-06 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K1-04
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-16
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K17-08
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K5-06 |
| filingDate |
2011-10-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_0ec7695741d1bd55a5962e2859e448b5
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b2e29729ece8e7cf87a5af2c3fe1359b
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_9dd868e1792c96852a2a3f4c912da3de
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b92723b6b2fcb33cba64aedf893a020b
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_35471276821f7ae11dbc62139d0c6f0f |
| publicationDate |
2013-11-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
KR-20130127446-A |
| titleOfInvention |
Diketopiperazine Forming Dipeptidyl Linkers |
| abstract |
The present invention relates to a method for homogeneous solution phase peptide synthesis (HSPPS) of N-terminal peptide fragment PEP-N and C-terminal peptide fragment C-PEP, wherein C-PEP is a C-terminal protecting group comprising a handle group HG. Carries a specific diketopiperazine (DKP) comprising, wherein the HG is linked to the C-terminus of the peptide fragment; As such, the specific DKPs comprising C-terminal protecting groups can be selectively cleaved from the peptide as C-terminal protecting groups commonly used. Using these DKPs and HGs comprising C-terminal protecting groups, certain process steps in convergent peptide synthesis based on the combination of HSPPS and solid phase peptide synthesis (SPPS) can be avoided. The invention also relates to a process for preparing such specifically protected fragment C-PEP by SPPS by using linkers comprising specific dipeptides and HG to link increasing peptide chains to the resin (peptide fragments) The linker forms the DKP group when C-PEP is cleaved from the supportive resin); It also relates to an intermediate of the above production method. |
| priorityDate |
2010-10-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |