abstract |
The present invention relates to a composition for the prophylaxis and treatment of inflammatory diseases or allergic diseases containing a complex herbal extract consisting of sunbok, habaek, Jeonho and guluin as an active ingredient, the extract of the present invention is bone marrow-derived mast cells (BMMC Inhibits COX-2 dependent PGD 2 production and leukotriene C 4 (LTC 4 ) production and inhibits NO and cytokine (TNF-α, IL-1, IL-6) production in macrophages after LPS stimulation And anti-inflammatory, anti-allergic and anti-asthmatic effects that inhibit serum IgE levels and inhibit the production of IL-4, IL-5, IL-10, and IL-17 in bronchoalveolar lavage fluid in ovalbumin-induced asthma models By confirming, it can be used in the pharmaceutical composition for the prevention and treatment of inflammatory diseases or allergic diseases. |