| abstract |
The present invention provides recombinant antigen binding regions specific for CD38, and antibodies and functional fragments comprising such antigen binding regions, which play an essential role in a variety of disorders or diseases. Thus, the antibody can be used, for example, in the treatment of hematologic malignancies, such as multiple myeloma. The antibodies of the invention can also be used in the field of diagnosis and to investigate the role of CD38 in the progression of disorders associated with malignant tumors. The invention also provides a kit comprising a nucleic acid sequence encoding the antibody described above, a vector comprising the same, a pharmaceutical composition, and instructions for use. The invention also provides isolated novel epitopes of CD38 and methods of use thereof. [Index] Anti-CD38 antibodies, antigen binding regions, epitopes, blood disorders |