| abstract |
The process for the preparation of 2,2-difluoroethylamine of formula I CHF 2 CH 2 NH 2 comprises steps (i) and (ii). In step (i), 2,2-difluoro-1-halogen ethane of formula II CHF 2 -CH 2 Hal is reacted with an acid scavenger, i.e. a compound capable of removing the hydrohalogen compound liberated during the reaction. Reacted with the benzylamine compound of formula III. Hal in formula (II) represents chlorine, bromine or iodine, in formula (III) R 1 represents hydrogen or C 1 -C 12 -alkyl, R 2 is hydrogen, halogen, C 1 -C 12 -alkyl or C 1 -C 6 -alkoxy. In step (ii), the N-benzyl-2,2-difluoroethane amine compound obtained in step (i) is catalytically hydrogenated to form 2,2-difluoroethylamine of formula (I) or a salt thereof. . (III) |