| abstract |
Compounds having the above structure or salts thereof are used to reduce or treat the likelihood of developing androgen-dependent diseases such as prostate cancer, benign prostatic hyperplasia, polycystic ovary syndrome, acne, hirsutism, seborrhea, androgenetic alopecia, and male baldness. . These compounds may be formulated with a pharmaceutically acceptable diluent or carrier or made in any pharmaceutical dosage form. Some of these compounds having tissue specific antiandrogen activity and tissue specific androgen activity can be used to reduce the risk of developing diseases associated with androgen impairment loss or to treat such diseases. Combinations with other pharmaceutically active agents are also disclosed. |