| abstract |
The present invention provides ligands that bind to and regulate the action of CLEC-2. The nucleic acid CLEC-2 ligand described herein can inhibit CLEC-2 mediated platelet aggregation, and also CLEC-2 mediated processes such as thrombus formation, tumor metastasis, lymphangiogenesis, HIV transmission, inflammatory response, cytokine production and phagocytosis It provides the use to control. In addition, the present invention describes modulator molecules capable of reversing the activity of CLEC-2 ligands both in vitro and in vivo and ex vivo. |