| abstract |
The present invention relates to a biomarker for diagnosing acute atherosclerosis in a human, and more particularly, to a biomarker for diagnosing acute atherosclerosis in a human, which is characterized by a marked increase in the expression level in atherosclerotic serum than in a serum of a stable atherosclerosis patient. And to the use of Fetuin-B for use as a biomarker. The present invention makes it possible to diagnose acute atherosclerosis, which is still unknown, with Fetuin-B, a serum protein in patients with acute atherosclerosis, in advance. In addition, the protein of the present invention not only promotes T-cell migration but also increases the activity of matrix metalloproteinases (MMP) -2, which is closely related to atherosclerotic rupture, As the expression level in acute atherosclerotic serum is significantly increased compared to serum, it can be utilized as a biomarker of acute atherosclerosis and can be useful in the development of diagnostic kits and therapeutic agents for acute atherosclerosis. |