| abstract |
The present invention is crosslinked by a bifunctional vinyl derivative, comprising three monomers selected from 1-vinylpyrrolidone (VP), N-isopropylacrylamide (NIPAM) and esters of maleic anhydride and polyethylene glycol (MPEG) It relates to a polymer of formula (I) comprising a unit and substantially free of each toxic monomeric impurity and of high purity, biomiscible, non-biodegradable and non-toxic and a process for preparing the same. The invention also relates to nanoparticulate pharmaceutical compositions of poorly water soluble drugs or compounds comprising the polymers of the invention, which are convenient, low toxicity and safe for bedside administration to patients in need thereof. The invention also relates to a method for the highly selective preparation of nanoparticulate pharmaceutical compositions of poorly water soluble drugs or compounds. |