| abstract |
The present invention relates to a composition for the prevention or treatment of hypoxic ischemia, and more particularly to a composition for preventing or treating hypoxic ischemia comprising, as an active ingredient, an agent for inhibiting expression or activity of Bag3 gene or protein expressed from the gene . According to the present invention, the Bag3 gene whose expression is increased in hypoxic ischemic astrocytes can be used as a marker for diagnosing hypoxic ischemia, and the expression or activity inhibitor of Bag3 gene or protein can be used as a marker for hypoxic ischemia And exhibits excellent neuronal cell protection effect, so that it can be usefully used as a preventive or therapeutic agent for hypoxic ischemia. |