| abstract |
The present invention relates to a method for removing, reducing or preventing bacterial biofilm by a fusion protein comprising endolicin, autolysine or bacteriocin fused to a membrane or peptide having LPS disrupting activity. The present invention further relates to fusion proteins for use as a medicament, in particular as a medicament for the treatment or prevention of Gram-negative and / or Gram-positive bacterial infections associated with bacterial biofilms as diagnostic means, disinfectants or cosmetic ingredients. The invention also relates to Gram-negative and / or Gram-positive bacteria associated with bacterial biofilms of foodstuffs, food processing equipment, food processing plants, surfaces in contact with food, medical devices, surfaces in hospitals and surgery. To the removal or reduction or prevention of contamination. Moreover, the present invention relates to the use of said fusion protein as a diagnostic means in medical, food or feed or environmental diagnostics associated with bacterial biofilms. |