| abstract |
The present invention relates to an antibody in which a motif consisting of an amino acid or peptide including one or more cysteine residues is bound to the end of the parent antibody, in particular to the heavy chain end, and a modified antibody-drug conjugate (mADC, Antibody-Drug) to which such an antibody and a drug are bound. Conjugate) and a method for preparing the antibody or modified antibody-drug conjugate. The modified antibody-drug conjugate (mADC) according to the present invention can accurately deliver a drug to a target cell due to the high specificity of the antigen of the antibody included in the conjugate, thereby increasing the therapeutic effect and high Despite its effectiveness, it can improve the utilization of drugs, especially anti-cancer drugs, which have limited use due to toxicity. The present invention also relates to a composition for the treatment of diseases, in particular cancer, using the modified antibody-drug conjugates. |