| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_1d1750b578ca9a780678f6b9b9c8b87d |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N2333-11
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2310-16 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-56983
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-711
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-115 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-569
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-70
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-115
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-7088 |
| filingDate |
2012-02-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_291e998470d7650ce8078ec80f5f9da3
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ac048235f093c01cf355f34369dfdfea
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e49986ebc6f28956913bba3772528959
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_280c576d8831eed226cfc2321712da7a |
| publicationDate |
2013-08-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
KR-20130092225-A |
| titleOfInvention |
Aptamers that specifically bind to the NS1 protein of influenza viruses and pharmaceutical compositions comprising the same |
| abstract |
The present invention relates to oligonucleotide aptamers of a specific sequence that inhibits the activity of influenza virus, the causative agent of acute respiratory diseases, and in particular, has a specific affinity for antibodies beyond the non-structural 1 (NS1) protein of influenza viruses. It has the effect of inhibiting the ability of host cell Retinoic acid-inducible gene I (RIG-I) and viral NS1 protein to bind. The nucleotide molecule of the present invention has a target affinity over the antibody, is significantly smaller in size than the antibody, and can bind with the target molecule with high binding strength. In addition, it is not sensitive to temperature changes and can be regenerated quickly even if denatured. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/KR-20160001480-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2019035763-A1 |
| priorityDate |
2012-02-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |