http://rdf.ncbi.nlm.nih.gov/pubchem/patent/KR-20130088807-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_17c6c7da627b7bead7208250127b52c2 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-17 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K19-00 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P37-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K19-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-17 |
| filingDate | 2013-01-31-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_28ea53379d3ae40adf0d36729badf68b http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_1d092c7d51e5fcd81c892c42542d3b47 |
| publicationDate | 2013-08-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | KR-20130088807-A |
| titleOfInvention | New CTL--4IGG Fusion Protein |
| abstract | The present invention provides a CTLA-4IgG fusion protein in which lysine, an amino acid at the C terminus of an immunoglobulin CH3 domain residue, is substituted with cysteine, an immunosuppressive pharmaceutical composition comprising the CTLA-4IgG fusion protein as an active ingredient, and CTLA-4IgG fusion. It relates to a method for enhancing the binding force between the CTLA-4IgG fusion protein and the lipid vehicle, comprising the step of: replacing the lysine amino acid of the C-terminal of the protein with cysteine. The CTLA-4IgG fusion protein according to the present invention effectively binds to a lipid vehicle and inhibits T cells with high activity by replacing lysine, an amino acid at the C terminus of an immunoglobulin CH3 domain residue with cysteine, an effective autoimmune disease therapeutic agent. Or it may be used as a pharmaceutical composition for suppressing immune such as organ transplant inhibitors. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2015182953-A1 |
| priorityDate | 2012-01-31-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 414.