abstract |
The present invention relates to a method for preparing tetrabenazine (TBZ) and dihydrotetrabenazine (DTBZ), and more particularly, to 6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline and Using 4-methyl-2- (3- (trimethylsilyl) prop-1-en-2-yl) pentane as starting material, the alkylation reaction, the aza-prince cyclization reaction in the presence of an oxidant, and the oxidation reaction were sequentially performed. The present invention relates to a method for producing tetrabenazine (TBZ) and dihydrotetrabenazine (DTBZ) by a brief and short reaction process. |