| abstract |
The present invention relates to a method for preparing an organofluoro compound labeled with radioisotope fluorine-18, and more particularly, by reacting an alkyl halide or alkyl sulfonate with [ 18 F] fluoride in the presence of a metal salt or an ammonium salt. organic [18 F] a method for preparing a compound as fluoro, to a method of producing a fluoro-organic [18 F], which is characterized by using a glycol represented by the general formula (1) compound as a catalyst. In the present invention, by using glycol as a catalyst for nucleophilic substitution reaction, one of the alcohol functional groups at both ends of the glycol is intermolecular reaction through sulfonate of leaving group and hydrogen bond with [ 18 F] fluoride. By showing the same effect as the reaction can be expected to improve the yield as the reaction rate increases. In addition, the use of glycol in a catalytic amount is useful for the production of radiopharmaceuticals labeled with [ 18 F] fluoride by reducing the formation of side reactions while compensating for the disadvantages of using alcohol as a solvent. |