http://rdf.ncbi.nlm.nih.gov/pubchem/patent/KR-20130083972-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_3dbb3abb710cb67674f2e944f6e4fc13 |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q2600-158 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q2600-178 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-1138 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-63 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q1-68 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-63 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12Q1-68 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-11 |
| filingDate | 2012-01-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_046528be7be311dadd128cc895264e0d |
| publicationDate | 2013-07-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | KR-20130083972-A |
| titleOfInvention | The alteration of signal transduction by applying endorphin neuronal cell line including shsy5y cell line with increased hsa-mir-598 mirna expression |
| abstract | PURPOSE: A method for increasing the expression of hsa-miR-598 miRNA and changing a signal transduction system by treating neuronal cells with endorphin is provided to show the same effect as endorphin by adding an antagomer or miRNA which has the same sequence as the antagomer using hsa-miR-598 miRNA. CONSTITUTION: A method for mimicking the effect of endorphin and a method for supplementing a specific signal comprise the step of directly treating a neuronal cell line including in vitro cultured SHSy5y cells or treating with an antagomer. The expression of proteins is suppressed by treating the cell line with endorphin and increasing the expression level of hsa-miR-598. The proteins are jagged 1 (Alagille syndrome), thrombospondin 2, lin-28 homolog (C. elegans), pantothenate kinase 1, heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa), zinc finger E-box binding homeobox 2, myelin protein zero (Charcot-Marie-Tooth neuropathy 1B), homeodomain interacting protein kinase 2, homeobox A3, prickle homolog 2 (Drosophila), and deltex 4 homolog (Drosophila). When endorphin is added, hsa-miR-598 miRNA is increased and the expression level of the proteins is reduced by targeting mRNA of a specific molecule. |
| priorityDate | 2012-01-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 75.