| abstract |
The present invention includes a) S- [2-([[1- (2-ethylbutyl) -cyclohexyl] -carbonyl] amino) phenyl] 2-methylpropanethioate, and b) croscarmellose sodium It relates to a composition to be. In addition, the invention provides a) S- [2-([[1- (2-ethylbutyl) -cyclohexyl] -carbonyl] amino) phenyl] 2-methylpropanethioate, finely divided crospovidone, microcrystalline cellulose Mixing and granulating croscarmellose sodium and hydroxypropyl methylcellulose; b) spraying up to 0.5% by weight of hydroxypropyl methylcellulose in the granules obtained according to step a) in water or in 10 to 30% by weight of ethanol / 70 to 90% by weight of water. step; c) drying the granules; And d) blending microcrystalline cellulose, colloidal silicon dioxide, and sodium stearyl fumarate with the dry granules obtained according to step c) above. |