| abstract |
The present invention relates to antibodies which bind to IL-12p40 binding protein, in particular human interleukin-12 (hIL-12) and / or human IL-23 (hIL-23). In particular, the present invention relates to chimeric, CDR grafted antibodies and humanized antibodies. Preferred antibodies have high affinity for hIL-12 and / or hIL-23 and neutralize hIL-12 and / or hIL-23 activity in vitro and in vivo. The antibody of the present invention may be a full length antibody or antigen binding portion thereof. Methods of making and using the antibodies of the invention are also provided. An antibody or portion of an antibody of the present invention detects hIL-12 and / or hIL-23 and detects hIL-12 and / or Useful for inhibiting hIL-23 activity. |