| abstract |
The present invention relates to pyrazine and pyridine compounds useful as inhibitors of ATR protein kinases. In addition, the present invention provides a pharmaceutically acceptable composition comprising a compound of the present invention; Methods of treating various diseases, disorders and conditions using the compounds of the present invention; A process for preparing a compound of the present invention; An intermediate for preparing a compound of the present invention; And methods of using the compounds in in vitro applications such as the study of kinases in biological and pathological phenomena, the study of intracellular signaling pathways mediated by these kinases, and the comparative evaluation of novel kinase inhibitors. Compounds of the invention have formula i, wherein the variables are as defined herein. Formula I |