| abstract |
The present invention relates to novel benzamide derivatives and their pharmaceutical uses, and more particularly to novel benzamide derivatives having the structural formula (1) or a pharmaceutically acceptable salt thereof and a method for the prevention of pain or pruritus Or therapeutic compositions. The novel benzamide derivatives and their pharmaceutically acceptable salts according to the present invention exhibit excellent pain control effects and exhibit pain suppressing effects in neuropathic animal models as well as other pain-induced models such as formalin models, Chronic pain can be used to suppress various pain. In addition, it was confirmed that the anti-pruritic composition has anti-pruritic effect on the itching model applied to the mechanism and treatment concept of pain, so that the initial itching step is suppressed and treated to prevent skin damage or inflammation after scratching It is useful because it can be used for the fundamental treatment of atopy. |