abstract |
Brazilin of the present invention increased the viability due to injury of UV-stimulated HaCaT and increased gene expression of Bcl-2, Bax and the like that inhibit apoptosis. In addition, by inhibiting the gene expression of COX-2, iNOS, TNF-α, c-fos, and c-jun increased by UV, it is useful for preventing and improving skin aging by confirming inhibition of aging and inhibition of UV-induced skin damage. A composition can be provided. |