| abstract |
FIELD OF THE INVENTION The present invention relates to certain hydroxy propionic acid derivatives and methods of their synthesis, and also to pharmacological compositions comprising the compounds of the present invention, and to the overexpression and overactivation of matrix metalloproteinases using the compounds. Asthma, rheumatoid arthritis, COPD, rhinitis, degenerative arthritis, psoriatic arthritis, psoriasis, pulmonary fibrosis, pneumonia, acute respiratory distress syndrome, periodontitis, multiple sclerosis, gingivitis, atherosclerosis, dry eye, restenosis and ischemic heart failure It provides a method for treating causing endovascular hyperplasia, stroke, kidney disease, tumor metastasis and other inflammatory diseases. |