abstract |
The present invention provides compounds of the following formulas (I), (II) and (III) [Wherein R1, R2, R3, R4, R5, R8, R9, R10 and X have the meanings indicated in the claims] And / or physiologically acceptable salts, tautomers and stereoisomers thereof, and mixtures of all ratios thereof. Compounds of formula (I) can be used for inhibition of serine / threonine protein kinases and for sensitization of cancer cells to anticancer agents and / or ionizing radiation. The object of the present invention is also the use of a compound of formula (I) in the prevention, treatment or control of onset of cancer, tumors, metastases or angiogenic disorders in combination with radiotherapy and / or anticancer agents. Further, the present invention relates to a compound of formula (I) by reacting a compound of formula (II) or (III) and converting the base or acid of the compound of formula (I) to one of the salts of It relates to a manufacturing method. |