| abstract |
The present invention provides an N 1 -cyclic amine-N 5 -substituted biguanide derivative represented by Formula 1 or a pharmaceutically acceptable salt thereof, a preparation method thereof, and a pharmaceutical composition comprising the same as an active ingredient. The biguanide derivative of the present invention exhibits an excellent activating effect of AMPK involved in regulating energy metabolism even at a small dose compared to conventional drugs, thereby exhibiting anticancer effect including cancer cell proliferation inhibition and cancer recurrence and metastasis. In addition, AMPK activation exhibits excellent hypoglycemic and lipid-lowering effects and can be useful for the treatment of diabetes, obesity, hyperlipidemia, hypercholesterolemia, fatty liver, coronary artery disease, osteoporosis, polycystic ovary syndrome, and metabolic syndrome. . [Formula 1] |