abstract |
The present invention provides isolated human monoclonal antibodies that bind to IFNAR-1 and inhibit the biological activity of type I interferon. Also provided are immune conjugates, bispecific molecules and pharmaceutical compositions comprising the antibodies of the invention. The present invention includes a method of treating an autoimmune disease, transplant rejection, or graft-versus-host reaction using an antibody of the invention, the method of inhibiting a type I interferon-mediated disease using the antibody of the invention. to provide. |