abstract |
It is an object of the present invention to provide a method for proliferating cardiomyocytes using miRNA that promotes proliferation of cardiomyocytes, a vector for treating heart disease, a pharmaceutical composition for treating heart disease, and the like. Provided are a method of proliferating cardiomyocytes using miRNAs having a proliferation promoting effect on cardiomyocytes, a vector for treating heart disease comprising the miRNA, a pharmaceutical composition for treating heart disease comprising the vector, and the like. As miRNAs, particularly, miRNAs selected from the group consisting of mature miRNAs miR-148a, miR-148b, miR-152 and miR-373, precursors of the miRNAs, and variants and analogs thereof are preferable. |