Predicate |
Object |
assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_e04a9c30b01a6909696dc92e883f241c |
classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2317-732 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2317-92 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2317-734 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2317-53 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2317-526 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2317-522 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2317-21 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2317-41 |
classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-54 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-475 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-435 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-18 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-17 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K39-395 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K48-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K16-2887 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K16-28 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K16-18 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K16-22 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K16-24 |
classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-13 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K39-395 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K16-18 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-63 |
filingDate |
2011-02-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_1c8b967a0354863f7c6bd8d8186f7d50 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_907f7a372994dc2c0994bde5e69a7e79 |
publicationDate |
2013-01-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
publicationNumber |
KR-20130002987-A |
titleOfInvention |
Modified antibody composition |
abstract |
Of the N-glycoside-linked sugar chains that bind to the Fc region of the antibody, the sugar chains that bind to the Asn at the 297th are involved in the activity or stability of the antibody, but the extra sugar chains other than the 297th are active through the normal region of the antibody. There is a possibility of affecting the homogeneity as a drug or an antibody drug. Therefore, a method of controlling the extra sugar chain which binds to Asn residues other than EU index 297th among the N-glycoside binding sugar chains which couple | bond with the Fc region of an antibody is calculated | required. The present invention relates to an amino acid residue constituting the Asn-X-Ser / Thr (X is an amino acid residue other than Pro) sequence other than the EU index 297-299th of the Fc region of a human IgG antibody, wherein Asn is replaced with another amino acid residue. A modified antibody composition and at least one modified antibody composition fragment having at least one amino acid modification selected from amino acid modification of X, amino acid modification from X to Pro, and amino acid modification from Ser / Thr to another amino acid residue are provided. |
isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/KR-20160056940-A |
priorityDate |
2010-03-02-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
type |
http://data.epo.org/linked-data/def/patent/Publication |