| abstract |
The present invention relates to a pyrazol-4-yl-heterocyclyl-carboxamide compound of formula (I), or a stereoisomer, geometric isomer, tautomer or pharmaceutically acceptable salt thereof, which comprises: inhibition of Pim kinase, And for the treatment of disorders mediated by Pim kinases, such as cancer. (I) In this formula, X is a thiazolyl, picolinyl, pyridinyl, pyrimidinyl, or fluoro-pyridinyl ring. Also disclosed are methods of using the compounds of formula (I) for in vitro, in situ and in vivo diagnosis, prevention or treatment of such disorders or associated pathological symptoms in mammalian cells. |