abstract |
The present invention provides antisense oligonucleotides that modulate the expression and / or function of pyrroline-5-carboxylate reductase 1 (PYCR1), in particular the natural antisense of pyrroline-5-carboxylate reductase 1 (PYCR1) polynucleotides. It relates to antisense oligonucleotides that target polynucleotides. The present invention also relates to the identification of such antisense oligonucleotides and their use in the treatment of diseases and disorders associated with the expression of PYCR1. |