http://rdf.ncbi.nlm.nih.gov/pubchem/patent/KR-20120120396-A
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D487-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D498-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-28 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D403-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D471-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-437 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P25-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D403-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D471-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-437 |
| filingDate | 2011-01-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2012-11-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | KR-20120120396-A |
| titleOfInvention | Gamma Secretase Adjuster |
| abstract | The present invention relates to a compound of formula (I) or a pharmaceutically active acid addition salt thereof: Formula I In this formula, R 1 and R 1 ′ are independently of each other hydrogen, halogen, lower alkoxy or cyano; R 2 is lower alkyl, halogen, lower alkoxy, lower alkyl substituted by halogen, lower alkoxy substituted by halogen, lower alkyl substituted by OR, ═O, —C (O) O—lower alkyl, —C (O) NH-lower alkyl, cyano, CH 2 -O-lower alkyl, cycloalkyl, NRR ', -O- (CH 2 ) o -phenyl optionally substituted with halogen; Halogen,-(CH 2 ) o -cyano, lower alkyl, lower alkyl substituted by halogen, lower alkyl substituted by hydroxy, C (O) H, -CH 2 -NH 2- , -CH 2 -NH- C (O) O-lower alkyl, -CH 2 -NH-C (O) -lower alkyl, -CH 2 -NH-lower alkyl, -CH 2 -NH-S (O) 2 -lower alkyl, lower alkoxy, And-(CH 2 ) o -phenyl optionally substituted with one, two or three substituents selected from lower alkoxy substituted with halogen; -(CH 2 ) o -cycloalkyl; -(CH 2 ) optionally substituted with halogen, CF 3 , lower alkyl, -CH 2 CN, -C (O) -lower alkyl, -C (O) O-lower alkyl or S (O) 2 -lower alkyl o -heterocycloalkyl; Heteroaryl selected from the group consisting of furanyl, pyrazinyl, pyridinyl, benzoxazolyl and benzoimidazolyl optionally substituted with lower alkyl; Or 4-methyl-3,4-dihydro-2H-benzo [1,4] oxazine; R and R 'are independently of each other hydrogen or lower alkyl; o is 0 or 1; R 3 may occur one or two times and is lower alkyl; A is ego; R 2 ′ is hydrogen, lower alkyl, lower alkyl substituted with halogen, C (O) -lower alkyl, S (O) 2 -lower alkyl, or phenyl optionally substituted with halogen; Hetaryl is a 5 or 6 membered N, S or O containing heteroaryl group; n is 0, 1, 2 or 3; When n is 2 or 3, R 2 may or may not be the same. The compounds of formula (I) of the present invention are modulators of amyloid beta and thus diseases associated with the deposition of beta-amyloid in the brain, in particular Alzheimer's disease, and other diseases such as cerebral amyloid angiopathy, Dutch amyloidogenic hereditary cerebral hemorrhage (HCHWA-D ), Multiple infarction dementia, boxer dementia and Down's syndrome. |
| priorityDate | 2010-02-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
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